Open AccessMethanol extract of wheatgrass induces G1 cell cycle arrest in a p53-dependent manner and down regulates the expression of cyclin D1 in human laryngeal cancer cells-an in vitro and in silico approach
Author(s) -
Garima Shakya,
Sangeetha Balasubramanian,
Rukkumani Rajagopalan
Publication year - 2015
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.157715
Subject(s) - cyclin d1 , cell cycle checkpoint , cell cycle , cyclin a , cell growth , cyclin b1 , viability assay , cyclin b , cancer cell , chemistry , biology , biochemistry , apoptosis , cancer , cyclin dependent kinase 1 , genetics
Deregs been implicated in the malignancy of cancer. Since many years investigation on the traditional herbs has been the focus to develop novel and effective drug for cancer remedies. Wheatgrass is a medicinal plant, used in folk medicine to cure various diseases. The present study was undertaken to gain insights into antiproliferative effect of methanol extract of wheatgrass.