Open AccessEffect of three fatty acids from the leaf extract of Tiliacora triandra on P-glycoprotein function in multidrug-resistant A549RT-eto cell line
Author(s) -
Chutima Kaewpiboon,
Pakorn Winayanuwattikun,
Tikamporn Yongvanich,
Preecha Phuwapraisirisan,
Wanchai Assavalapsakul
Publication year - 2014
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.139779
Subject(s) - etoposide , phytol , multiple drug resistance , chemistry , efflux , rhodamine 123 , cell culture , chromatography , biochemistry , biology , chemotherapy , genetics , antibiotics
Cancer cells have the ability to develop resistance to chemotherapy drugs, which then leads to a reduced effectiveness and success of the treatment. Multidrug resistance (MDR) involves the resistance in the same cell/tissue to a diverse range of drugs of different structures. One of the characteristics of MDR is an overexpression of P-glycoprotein (P-gp), which causes the efflux of the accumulated drug out of the cell. The MDR human non-small cell lung carcinoma cell line with a high P-gp expression level (A549RT-eto) was used to investigate the bioactive compounds capable of reversing the etoposide resistance in this cell line.