Open AccessAnti-melanogenic activity of the novel herbal medicine, MA128, through inhibition of tyrosinase activity mediated by the p38 mitogen-activated protein kinases and protein kinase signaling pathway in B16F10 cells
Author(s) -
Aeyung Kim,
Jin Yeul
Publication year - 2014
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.139774
Subject(s) - microphthalmia associated transcription factor , tyrosinase , creb , protein kinase a , melanin , p38 mitogen activated protein kinases , kinase , mapk/erk pathway , chemistry , phosphorylation , pharmacology , biochemistry , biology , transcription factor , enzyme , gene
Recently, our research group developed MA128, a novel herbal medicine, and demonstrated that MA128 is effective for the treatment of asthma and atopic dermatitis (AD). In particular, postinflammatory hyper-pigmentation in AD mice was improved with MA128 treatment. Thus, in this study, we determined the effect of MA128 on melanogenesis and its underlying mechanism in murine B16F10 melanoma cells.