Open AccessMolecular docking studies of flavonoids for their inhibition pattern against β-catenin and pharmacophore model generation from experimentally known flavonoids to fabricate more potent inhibitors for Wnt signaling pathway
Author(s) -
Hira Iftikhar,
Sajid Rashid
Publication year - 2014
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.133269
Subject(s) - pharmacophore , wnt signaling pathway , chemistry , docking (animal) , fisetin , biochemistry , flavonoid , gsk 3 , myricetin , stereochemistry , signal transduction , kaempferol , medicine , nursing , antioxidant
Canonical Wnt signaling plays a key role in tumor cell proliferation, which correlates with the accumulation of β-catenin in cell due to inactivation of glycogen synthetase kinase-3 β. However, uncontrolled expression of β-catenin leads to fibromatosis, sarcoma and mesenchymal tumor formation. Recently, a number of polyphenolic compounds of naturally occurring flavonoid family have been screened for the inhibition of Wnt signaling.