Open AccessCompounds isolated from Ageratum houstonianum inhibit the activity of matrix metalloproteinases (MMP-2 and MMP-9): An oncoinformatics study
Author(s) -
Anupriya Verma,
Syed Mohd Danish Rizvi,
Sibhghatulla Shaikh,
Mohd. Afaque Ansari,
Shazi Shakil,
Fauzia Ghazal,
Mohammad Haris Siddiqui,
Mohd Haneef,
Ajijur Rehman
Publication year - 2014
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.126653
Subject(s) - matrix metalloproteinase , chemistry , autodock , docking (animal) , enzyme , stereochemistry , in silico , biochemistry , veterinary medicine , medicine , gene
In osteosarcoma tissue, both MMP-2 and MMP-9 are over expressed compared to their expression in non-affected stromal tissue. Hence, gelatinases are attractive targets for anti-osteosarcoma drugs.