Open AccessTreatment-resistant schizophrenia: Evidence-based strategies
Author(s) -
Susanne Englisch,
Mathias Zink
Publication year - 2012
Publication title -
mens sana monographs
Language(s) - English
Resource type - Journals
eISSN - 0973-1229
pISSN - 1998-4014
DOI - 10.4103/0973-1229.91588
Subject(s) - polypharmacy , schizophrenia (object oriented programming) , antipsychotic , mood , clozapine , cognition , psychiatry , psychology , placebo , medicine , pharmacology , alternative medicine , pathology
Treatment-resistant symptoms complicate the clinical course of schizophrenia, and a large proportion of patients do not reach functional recovery. In consequence, polypharmacy is frequently used in treatment-refractory cases, addressing psychotic positive, negative and cognitive symptoms, treatment-emergent side effects caused by antipsychotics and comorbid depressive or obsessive-compulsive symptoms. To a large extent, such strategies are not covered by pharmacological guidelines which strongly suggest antipsychotic monotherapy. Add-on strategies comprise combinations of several antipsychotic agents and augmentations with mood stabilizers; moreover, antidepressants and experimental substances are applied. Based on the accumulated evidence of clinical trials and meta-analyses, combinations of clozapine with certain second-generation antipsychotic agents and the augmentation of antipsychotics with antidepressants seem recommendable, while the augmentation with mood stabilizers cannot be considered superior to placebo. Forthcoming investigations will have to focus on innovative pharmacological agents, the clinical spectrum of cognitive deficits and the implementation of cognitive behavioral therapy.