Open AccessNeuropathic pain due to fibromatosis: Does anticancer treatment help?
Author(s) -
David Mathew,
Reena George,
Jenifer Jeba,
Sunita Susan Varghese
Publication year - 2011
Publication title -
indian journal of palliative care/indian journal of palliative care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 26
eISSN - 1998-3735
pISSN - 0973-1075
DOI - 10.4103/0973-1075.92349
Subject(s) - medicine , fibromatosis , radiation therapy , tamoxifen , neuropathic pain , brachial plexus , aggressive fibromatosis , surgery , anesthesia , cancer , breast cancer
Desmoid fibromatosis, although histologically benign, infiltrates local structures. The involvement of neural structures can lead to difficult neuropathic pain and the escalating use of analgesics. We report a patient with desmoid fibromatosis of the chest wall causing brachial plexus infiltration. As the tumor was locally invasive and unresectable, he was treated with radiation therapy and oral tamoxifen. On follow-up, there was significant pain relief, sustained reduction in the tumor size, and reduced analgesic requirement. Antineoplastic treatments like local radiation therapy and targeted systemic therapy with hormones or other agents can be considered in the management of selected unresectable desmoid fibromatosis to improve symptom control and reduce polypharmacy.