Open AccessEtiopathogenesis of orofacial clefting revisited
Author(s) -
Sudeendra Prabhu,
Rekha Krishnapillai,
Maji Jose,
Vishnudas Prabhu
Publication year - 2012
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.99074
Subject(s) - anomaly (physics) , pathogenesis , neuroscience , medicine , biology , psychology , pathology , physics , condensed matter physics
The cleft anomaly may be more ancient than the man himself. It is one of the most common developmental malformations reported in the literature. There are number of intriguing theories regarding its etiopathogenesis, each of which has some evidence in its favor. This review highlights all the genetic and environmental etiologic factors and focuses on its pathogenesis.