Open AccessImmunohistochemical expression of cyclin D1 in ameloblastomas and adenomatoid odontogenic tumors
Author(s) -
Harsh Kumar,
Vandana Raghunath,
G.C. Shiva Kumar
Publication year - 2011
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.86685
Subject(s) - ameloblastoma , adenomatoid odontogenic tumor , pathology , immunohistochemistry , biology , staining , cyclin d1 , adamantinoma , odontogenic tumor , cell cycle , medicine , cell , anatomy , maxilla , odontogenic , genetics
Cyclin D1, a member of G1 cyclins, controls the cell-cycle transit from the G1 to S phase. The deregulation and overexpression of cyclin D1 has been revealed in many tumors of diverse histogenesis. Ameloblastoma is the most frequently encountered odontogenic tumor known for its local invasiveness and a high tendency to recur. The adenomatoid odontogenic tumor is a benign, nonaggressive tumor with a limited growth and no tendency to recur.