Open AccessImmunohistochemical analysis of angiogenesis by CD34 and mast cells by toluidine blue in different grades of oral squamous cell carcinoma
Author(s) -
PramodSangamesh Ingaleshwar,
Siddharth Pandit,
Dinkar Desai,
CPramod Redder,
AkhilS Shetty,
KM Mithun
Publication year - 2016
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.190950
Subject(s) - angiogenesis , cd34 , pathology , immunohistochemistry , mast cell , medicine , tumor progression , basal cell , neovascularization , cancer , biology , cancer research , immunology , stem cell , genetics
Angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and immune cells. It has been reported to be associated with progression, aggressiveness and metastases of various malignant tumors including oral squamous cell carcinoma (OSCC). Similarly, mast cells have also been reported to play a role in tumor progression and metastases by promoting angiogenesis.