Open AccessHuman MutL homolog 1 immunoexpression in oral leukoplakia and oral squamous cell carcinoma: A prospective study in Indian population
Author(s) -
Narendra T Chaudhari,
Jagdish Vishnu Tupkari,
Tabita Joy,
Manisha S. Ahire
Publication year - 2016
Publication title -
journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.190948
Subject(s) - leukoplakia , oral leukoplakia , dysplasia , basal cell , immunohistochemistry , pathology , p53 expression , carcinoma , medicine , statistical significance , oral mucosa , biology , gastroenterology , cancer
Mammalian mismatch repair system is responsible for maintaining genomic stability during repeated duplications, and human MutL homolog 1 (hMLH1) protein constitutes an important part of it. Various isolated studies have reported the altered expression of hMLH1 in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). Research is lacking in the quantitative estimation and comparison of hMLH1 expression in OL and OSCC.