Open AccessTo analyze the concomitant expression of human papillomavirus-16 in the pathogenetic model of p53-dependant pathway in oral squamous cell carcinoma
Author(s) -
Ajit Singh Rathore,
Nikita Gulati,
Devi Charan Shetty,
Abhishek Jain
Publication year - 2016
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.190896
Subject(s) - immunohistochemistry , human papillomavirus , polymerase chain reaction , hpv infection , basal cell , pathogenesis , cancer , cancer research , concomitant , pathology , medicine , cervical cancer , biology , oncology , gene , biochemistry
Oral squamous cell carcinoma (OSCC) accounts for 90% of all primary oral malignancies. Association between human papillomavirus (HPV) as a risk factor of cervical cancer is well known; there is a need to widen the knowledge for its role in oral cancer development. The viral E6 protein of HPV binds to p53 making it nonfunctional.