Open AccessQuantitative evaluation of microvessel density using CD34 in clinical variants of ameloblastoma: An immunohistochemical study
Author(s) -
Treville Pereira,
Shashibhushan Dodal,
Avinash Tamgadge,
Sudhir Bhalerao,
Sandhya Tamgadge
Publication year - 2016
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.180929
Subject(s) - ameloblastoma , cd34 , angiogenesis , pathology , immunohistochemistry , odontogenic tumor , microvessel , medicine , biology , cancer research , anatomy , odontogenic , stem cell , maxilla , genetics
Odontogenic epithelium plays an important role in the histogenesis of odontogenic tumors of the jaws. Ameloblastomas, which arise from odontogenic epithelium, are considered benign with little tendency to metastasize. Tumors require an adequate supply of oxygen and a way to remove their waste products. This can be achieved by angiogenesis. In situ quantification of the microvessel density (MVD) is a usual method for assessing angiogenesis. Moreover, angiogenesis may differ in subtypes of ameloblastomas and could play a role in determining the pattern of tumor growth.