Open AccessImmunohistochemical detection of the receptor activator of nuclear factor Kappa B ligand and c-fos in giant cell granuloma
Author(s) -
Atif Ahmed,
Charles L. Dunlap
Publication year - 2016
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.180928
Subject(s) - immunohistochemistry , kappa , pathology , activator (genetics) , receptor , chemistry , biology , microbiology and biotechnology , medicine , mathematics , geometry
Giant cell granuloma (GCG) is an intraosseous giant cell fibroblastic lesion that predominantly affects the jaw bones in children and adults. Despite its frequent local progression and destructive effect, it is traditionally considered reparative or reactive in nature. The receptor activator of nuclear factor Kappa B ligand (RANKL), a member of the tumor necrosis factor family and the transcription factor c-fos play a major role in osteoclast proliferation and differentiation. In this study, we examined the expression of RANKL and c-fos in lesional tissues from seven patients with GCG.