Open AccessSuccessful management of aluminium phosphide poisoning using intravenous lipid emulsion: Report of two cases
Author(s) -
Udismita Baruah,
Ameeta Sahni,
Harish C Sachdeva
Publication year - 2015
Publication title -
indian journal of critical care medicine/indian journal of critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 30
eISSN - 1998-359X
pISSN - 0972-5229
DOI - 10.4103/0972-5229.171412
Subject(s) - medicine , antidote , magnesium , emulsion , phosphine , hypoxia (environmental) , cytochrome c oxidase , pharmacology , toxicity , toxicology , biochemistry , enzyme , oxygen , chemistry , organic chemistry , biology , catalysis
Aluminum phosphide (ALP) is a cheap, easily available agricultural pesticide which causes lethal poisoning by liberation of phosphine and inhibition of cytochrome c oxidase thereby leading to cellular hypoxia. Although there is no known specific antidote, clinical trials are still going on. We present here two cases of ALP poisoning who were successfully managed by treatment with lipid emulsion and intravenous magnesium sulfate.