Open AccessFDG-PET findings in fronto-temporal dementia: A case report and review of literature
Author(s) -
Chidambaram Natrajan Balasubramanian Harisankar,
Bhagwant Rai Mittal,
Kanhaiyalal Agrawal,
Mohammed Labeeb Abrar,
Anish Bhattacharya,
Baljinder Singh,
Manish Modi
Publication year - 2011
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/0972-3919.90261
Subject(s) - medicine , dementia , positron emission tomography , frontotemporal lobar degeneration , neuroimaging , temporal lobe , disease , pathology , neuroscience , radiology , epilepsy , psychiatry , psychology , frontotemporal dementia
Fronto-temporal lobar degeneration (FTLD) is a clinically and pathologically heterogeneous syndrome, characterized by progressive decline in behavior or language associated with degeneration of the frontal and anterior temporal lobes. Three distinct clinical variants of FTLD have been described. Despite the difficulties, accurate diagnosis is critical because the clinical management differs for Alzheimer's disease (AD) and FTLD. Positron emission tomography with fluro-deoxy-glucose (FDG-PET) typically shows sufficient abnormalities that can be used to improve the accuracy of distinguishing AD from FTLD in individual cases. Though temporo-parietal hypometabolism is sensitive in diagnosis of AD, it is less specific. The importance of evaluating the cingulate and anterior temporal cortices for arriving at a diagnosis of FTLD is stressed.