Open AccessBone scintigraphic patterns in patients of tumor induced osteomalacia
Author(s) -
Ashwani Sood,
Kanhaiyalal Agarwal,
Jaya Shukla,
Reema Goel,
Varun Dhir,
Anish Bhattacharya,
Bhagwant Rai Mittal
Publication year - 2013
Publication title -
indian journal of nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 13
eISSN - 0972-3919
pISSN - 0974-0244
DOI - 10.4103/0972-3919.119541
Subject(s) - osteomalacia , medicine , fibroblast growth factor 23 , hypophosphatemia , bone remodeling , pathology , osteoporosis , calcium , parathyroid hormone
Tumor induced osteomalacia (TIO) or oncogenic osteomalacia is a rare condition associated with small tumor that secretes one of the phosphaturic hormones, i.e., fibroblast growth factor 23, resulting in abnormal phosphate metabolism. Patients may present with non-specific symptoms leading to delay in the diagnosis. Extensive skeletal involvement is frequently seen due to delay in the diagnosis and treatment. The small sized tumor and unexpected location make the identification of tumor difficult even after diagnosis of osteogenic osteomalacia. The bone scan done for the skeletal involvement may show the presence of metabolic features and the scan findings are a sensitive indicator of metabolic bone disorders. We present the bone scan findings in three patients diagnosed to have TIO.