Open AccessLate-onset myoclonic epilepsy in Down syndrome (LOMEDS): A spectrum of progressive myoclonic epilepsy — Case report
Author(s) -
C. M. Sharma,
Rajendra Kumar Pandey,
Banshi Lal Kumawat,
Dinesh Khandelwal
Publication year - 2016
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/0972-2327.173411
Subject(s) - myoclonic epilepsy , medicine , epilepsy , ataxia , pediatrics , progressive myoclonus epilepsy , myoclonic jerk , myoclonus , electroencephalography , trisomy , epilepsy syndromes , audiology , psychiatry , genetics , biology
Cognitive decline and epilepsy are well recognized complication of Down syndrome (DS). Here, we intend to present a case of 28 year old male who presented with progressive mental regression, gait ataxia and myoclonic jerking especially on awakening in morning. His EEG was normal and karyotyping revealed trisomy of chromosome 21. Very few cases had been described in literature of late-onset myoclonic epilepsy in DS. This is first case report from India and our aim is to propose the inclusion of this entity in the spectrum of progressive myoclonic epilepsies but still more cases are yet to be found.