Open AccessLimbic encephalitis with antibodies to glutamic acid decarboxylase presenting with brainstem symptoms
Author(s) -
Faruk İncecik,
Özlem Hergüner,
Dinçer Yıldızdaş,
Özden o Horoz,
Şeyda Beşen
Publication year - 2015
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/0972-2327.150628
Subject(s) - limbic encephalitis , glutamate decarboxylase , medicine , brainstem , antibody , stiff person syndrome , encephalitis , immunology , autoimmune encephalitis , pathology , autoantibody , enzyme , biology , biochemistry , virus
Limbic encephalitis (LE) is a neurological syndrome that may present in association with cancer, infection, or as an isolate clinical condition often accompanying autoimmune disorders. LE associated with glutamic acid decarboxylase antibodies (anti-GAD) is rare in children. Here, we characterized the clinical and laboratory features of a patient presenting with brainstem involvement with non-paraneoplastic LE associated with anti-GAD antibodies. In our patient, after plasma exchange, we determined a dramatic improvement of the neurological deficits.