Open AccessBrain stimulation for intractable epilepsy: Anterior thalamus and responsive stimulation
Author(s) -
Vibhor Krishna,
Andrés M. Lozano
Publication year - 2014
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/0972-2327.128671
Subject(s) - thalamus , medicine , stimulation , epilepsy , neuromodulation , deep brain stimulation , neuroscience , epilepsy surgery , brain stimulation , anesthesia , psychology , psychiatry , disease , radiology , parkinson's disease
Despite medications, resective surgery, and vagal nerve stimulation, some patients with epilepsy continue to have seizures. In these patients, other approaches are urgently needed. The biological basis of stimulation of anterior thalamic nucleus and epileptogenic focus is presented. Results from two large randomized controlled trials Stimulation of Anterior Nucleus of Thalamus for Epilepsy (SANTE) and Neuropace pivotal trial are discussed. Neuromodulation provides effective treatment for a select group of refractory epilepsy patients. Future investigations into the mechanism underlying 'response' to brain stimulation are desired.