Open AccessThe first report described as an important study: The association of mannose-binding lectin gene 2 polymorphisms in children with down syndrome
Author(s) -
Osman Demırhan,
Deniz Taştemir,
Ramazan Güneşaçar,
Ali İrfan Güzel,
Davut Alptekın
Publication year - 2011
Publication title -
indian journal of human genetics
Language(s) - English
Resource type - Journals
eISSN - 0971-6866
pISSN - 1998-362X
DOI - 10.4103/0971-6866.86176
Subject(s) - genotype , biology , mannan binding lectin , single nucleotide polymorphism , gene , haplotype , genetics , allele , restriction fragment length polymorphism , exon , microbiology and biotechnology , polymorphism (computer science)
Mannose-binding lectin gene 2 (MBL2) plays a very important role in the first line of host immune response in Down syndrome (DS). The importance of MBL2 gene polymorphisms in children with DS is unclear, and no research has addressed MBL2 gene polymorphisms in patients with DS. This is the first report describing an important association between MBL2 gene polymorphisms and infections in children with DS.