Open AccessMethylenetetrahydrofolate reductase polymorphism is not risk factor for Down syndrome in North India
Author(s) -
Vandana Rai,
Upendra Yadav,
Pradeep Kumar,
Sushil Kumar Yadav
Publication year - 2014
Publication title -
indian journal of human genetics
Language(s) - English
Resource type - Journals
eISSN - 0971-6866
pISSN - 1998-362X
DOI - 10.4103/0971-6866.142858
Subject(s) - methylenetetrahydrofolate reductase , odds ratio , homocysteine , genotype , allele , medicine , risk factor , genetics , biology , reductase , etiology , gastroenterology , endocrinology , gene , enzyme , biochemistry
Down syndrome (DS) is the most common cause of mental retardation of genetic etiology with the prevalence rate of 1/700 to 1/1000 live births worldwide. Several polymorphisms in folate/homocysteine metabolism pathways genes have been reported as a risk factor in women for bearing DS child, but very few studies investigated these polymorphisms in DS cases whether there are a risk factor for being DS or not.