Open AccessVitamin C attenuates chronic chlorpyrifos-induced alteration of neurobehavioral parameters in Wistar rats
Author(s) -
Suleiman Folorunsho Ambali,
Joseph Olusegun Ayo
Publication year - 2012
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.97211
Subject(s) - aché , righting reflex , glycogen , vitamin , vitamin c , chlorpyrifos , endocrinology , oxidative stress , toxicity , medicine , chemistry , vitamin e , acetylcholinesterase , reflex , antioxidant , biochemistry , biology , enzyme , pesticide , agronomy
Oxidative stress is one of the molecular mechanisms in chlorpyrifos toxicity. The present study was designed to evaluate the attenuating effect of vitamin C on chlorpyrifos-induced alteration of neurobehavioral performance and the role of muscle acetylchloinesterase (AChE), glycogen and lipoperoxidation in the accomplishment of this task.