Open AccessN-acetylcysteine, ascorbic acid, and methylene blue for the treatment of aluminium phosphide poisoning: Still beneficial?
Author(s) -
Farzad Gheshlaghi,
Mohamad Reza Lavasanijou,
Noushin Afshar Moghaddam,
Majid Khazaei,
Mohaddeseh Behjati,
Ziba Farajzadegan,
Ali Mohammad Sabzghabaee
Publication year - 2015
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.172255
Subject(s) - methylene blue , acetylcysteine , ascorbic acid , medicine , survival rate , antidote , toxicity , antioxidant , vitamin c , chemistry , pharmacology , biochemistry , food science , photocatalysis , catalysis
Intentional and accidental intoxication with aluminium phosphide (ALP) remains a clinical problem, especially in the Middle East region. Considering the high mortality rate besides lack of any recommended first option drug for its treatment, this study was aimed to compare the therapeutic effects of N-acetylcysteine (NAC), vitamin C (Vit C), and methylene blue; both in isolate and also in combination, for the treatment of ALP intoxication in a rat model.