Open AccessTerminalia chebula attenuates DMBA/Croton Oil-Induced oxidative stress and inflammation in Swiss albino mouse skin
Author(s) -
Ferial Majed,
Safees,
Summya Rashid,
Nemat Ali,
Syed Kazim Hasan,
Asif Rashid,
Ayaz Shahid,
Sarwat Sultana
Publication year - 2015
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.172252
Subject(s) - terminalia chebula , dmba , croton oil , oxidative stress , proinflammatory cytokine , pharmacology , lipid peroxidation , chemistry , antioxidant , nitric oxide synthase , inflammation , carcinogenesis , biochemistry , medicine , traditional medicine , immunology , enzyme , gene
The present study was designed to investigate underlying molecular mechanism for antitumorigenic potential of Terminalia chebula (TC) against chemically-induced skin tumorigenesis in Swiss albino mice. It is used as herbal medicine because it exhibits antioxidant, anti-inflammatory, and anticarcinogenic activity. However, the précised underlying mechanism remains to be elucidated.