Open AccessRifapentine-proliposomes for inhalation: In vitro and In vivo toxicity
Author(s) -
Arpana Patil-Gadhe,
Abhay Kyadarkunte,
Michael Pereira,
Gauri Jejurikar,
Milind S. Patole,
Arun Risbud,
Varsha Pokharkar
Publication year - 2014
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.155361
Subject(s) - rifapentine , in vivo , pharmacology , toxicity , cytotoxicity , inhalation , in vitro , median lethal dose , medicine , mycobacterium tuberculosis , alveolar macrophage , tuberculosis , chemistry , biology , macrophage , pathology , anesthesia , biochemistry , latent tuberculosis , microbiology and biotechnology
Oral therapy for pulmonary tuberculosis (TB) treatment suffers from the limitation of hepatic metabolism leading insufficient concentration of antitubercular (anti-TB) drugs in alveolar macrophage which harbors Mycobacterium tuberculosis (MTB). Targeted aerosol delivery of antituberculous drug to lung is efficient for treating local lung TB infection.