Open AccessNeuroprotective actions of clinoptilolite and ethylenediaminetetraacetic acid against lead-induced toxicity in mice Mus musculus
Author(s) -
Mahaboob P Basha,
Shabana Begum,
Bilal Ahmed Mir
Publication year - 2013
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.121666
Subject(s) - oxidative stress , lipid peroxidation , chemistry , catalase , superoxide dismutase , antioxidant , toxicity , neurotoxicity , glutathione , glutathione peroxidase , pharmacology , ethylenediaminetetraacetic acid , clinoptilolite , biochemistry , lead acetate , enzyme , biology , chelation , zeolite , organic chemistry , catalysis
Oxidative stress is considered as a possible molecular mechanism involved in lead (Pb(2+)) neurotoxicity. Very few studies have been investigated on the occurrence of oxidative stress in developing animals due to Pb(2+) exposure. Considering the vulnerability of the developing brain to Pb(2+), this study was carried out to investigate the effects of Pb(2+) exposure in brain regions especially on antioxidant enzyme activities along with ameliorative effects of ethylenediaminetetraacetic acid (EDTA) and clinoptilolite.