Open AccessEffects of fennel essential oil on cisplatin-induced nephrotoxicity in ovariectomized rats
Author(s) -
Safoora Mazaheri,
Mehdi Nematbakhsh,
Mehrnoosh Bahadorani,
Zahra Pezeshki,
Ardeshir Talebi,
Alireza Ghannadi,
Farzaneh Ashrafi
Publication year - 2013
Publication title -
indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.117256
Subject(s) - nephrotoxicity , blood urea nitrogen , creatinine , chemistry , ovariectomized rat , pharmacology , kidney , cisplatin , endocrinology , estrogen , saline , medicine , biochemistry , chemotherapy
Cisplatin (cis-diamminedichloroplatinum II (CDDP)) is an effective drug in cancer therapy to treat solid tumors. However, the drug is accompanied by nephrotoxicity. Previous reports indicated that estrogen has no protective role against CDDP-induced nephrotoxicity, but the role of phytoestrogen as an estrogenic agent in plants is not determined yet. The major composition of fennel essential oil (FEO) is trans-anethole that has estrogenic activity; so, we used FEO as a phytoestrogen source against CDDP-induced nephrotoxicity.