Open AccessNon invasive real-time monitoring of bacterial infection & therapeutic effect of anti-microbials in five mouse models
Author(s) -
Tarani Kanta Barman,
Madhvi Rao,
Ashish Bhati,
Krishna Kishore,
Gunjan Shukla,
Manoj Kumar,
Tarun Mathur,
Manisha Pandya,
Dilip J. Upadhyay
Publication year - 2011
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/0971-5916.90997
Subject(s) - antibiotics , staphylococcus aureus , pseudomonas aeruginosa , bioluminescence , in vivo , microbiology and biotechnology , streptococcus pneumoniae , biology , bioluminescence imaging , sepsis , bacteria , detection limit , bacterial colony , bacterial disease , immunology , luciferase , chemistry , cell culture , ecology , transfection , genetics , chromatography
In vivo imaging system has contributed significantly to the understanding of bacterial infection and efficacy of drugs in animal model. We report five rapid, reproducible, and non invasive murine pulmonary infection, skin and soft tissue infection, sepsis, and meningitis models using Xenogen bioluminescent strains and specialized in vivo imaging system (IVIS).