Open AccessAssay for identification of heterozygous single-nucleotide polymorphism (Ala67Thr) in human poliovirus receptor gene
Author(s) -
Shyam Sundar Nandi,
Deepa Kailash Sharma,
Jagadish M. Deshpande
Publication year - 2016
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/0971-5916.193281
Subject(s) - single nucleotide polymorphism , biology , snp , genotype , molecular inversion probe , poliovirus , gene , microbiology and biotechnology , genetics , polymerase chain reaction , virology , virus
It is important to understand the role of cell surface receptors in susceptibility to infectious diseases. CD155 a member of the immunoglobulin super family, serves as the poliovirus receptor (PVR). Heterozygous (Ala67Thr) polymorphism in CD155 has been suggested as a risk factor for paralytic outcome of poliovirus infection. The present study pertains to the development of a screening test to detect the single nucleotide (SNP) polymorphism in the CD155 gene.