Open AccessLevel of PAX5 in differential diagnosis of non-Hodgkin′s lymphoma
Author(s) -
Bhartendu Bharti,
Rajnikant Mishra,
Ratnakar Tripathi,
Sarita Mishra,
Mohan Kumar,
Manoj Pandey,
Rajnikant Mishra
Publication year - 2016
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/0971-5916.191747
Subject(s) - pax5 , cd19 , lymphoma , biology , b cell , microbiology and biotechnology , non hodgkin's lymphoma , cancer research , antibody , immunology , flow cytometry
The PAX5, a paired box transcription factor and B-cell activator protein (BSAP), activates B-cell commitment genes and represses non-B-cell lineage genes. About 14 transcript variants of PAX5 have been observed in human. Any alteration in its expression pattern leads to lymphogenesis or associated diseases and carcinogenesis in non-lymphoid tissues. Its mechanisms of function in pathophysiology of non-Hodgkin's lymphoma (NHL) are unclear. This study was intended to explore influence of PAX5 in cascade of NHL pathogenesis and diagnosis.