Open AccessHigh fms-like tyrosine kinase-3 (FLT3) receptor surface expression predicts poor outcome in FLT3 internal tandem duplication (ITD) negative patients in adult acute myeloid leukaemia: A prospective pilot study from India
Author(s) -
Surender Kumar Sharawat,
Vinod Raina,
Lalit Kumar,
Atul Sharma,
Radhika Bakhshi,
Sreenivas Vishnubhatla,
Ritu Gupta,
Sameer Bakhshi
Publication year - 2016
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/0971-5916.191740
Subject(s) - medicine , fms like tyrosine kinase 3 , survival analysis , oncology , proportional hazards model , tyrosine kinase , log rank test , receptor tyrosine kinase , mutation , receptor , biology , gene , genetics
Mutations in fms-like tyrosine kinase 3 (FLT3) receptor have significant role in assessing outcome in patients with acute myeloid leukaemia (AML). Data for FLT3 surface expression in relation to FLT3 internal tandem duplication (ITD) status and outcome are not available from India. The objective of the current study was to investigate adult patients with AML for FLT3 expression and FLT3 ITD mutation, and their association with long-term outcome.