Open AccessIs CXCL10/CXCR3 axis overexpression a better indicator of leprosy type 1 reaction than inducible nitric oxide synthase?
Author(s) -
Ira Sharma,
Avninder Singh,
Ashwani Kumar Mishra,
Laishram Chandreshwor Singh,
Vignesh Ramesh,
Sunita Saxena
Publication year - 2015
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/0971-5916.174554
Subject(s) - cxcr3 , cxcl10 , leprosy , biology , immunohistochemistry , pathology , nitric oxide synthase , inflammation , chemokine , immunology , medicine , chemokine receptor , nitric oxide , endocrinology
Leprosy type 1 reactions (T1R) are acute episodes of immune exacerbation that are a major cause of inflammation and nerve damage. T1R are diagnosed clinically and supported by histopathology. No laboratory marker is currently available that can accurately predict a T1R. Increased plasma and tissue expression of inducible nitric oxide synthase (i-NOS) and chemokine CXCL10 have been demonstrated in T1R. We studied the gene expression and immunoexpression of i-NOS, CXCL10 and its receptor CXCR3 in clinically and histopathologically confirmed patients with T1R and compared with non-reactional leprosy patients to understand which biomarker has better potential in distinguishing reaction from non-reaction.