Open AccessNon-nephronal hematuria misdiagnosed as C1q nephropathy: Look before you leap
Author(s) -
SN Mandal,
Ratan Jha,
R Fatima,
G Swarnalata
Publication year - 2012
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.98761
Subject(s) - medicine , macroscopic hematuria , microscopic hematuria , urology , urethritis , proteinuria , nephropathy , doxycycline , prednisolone , renal biopsy , urethra , dermatology , pathology , gastroenterology , biopsy , surgery , kidney , antibiotics , diabetes mellitus , endocrinology , microbiology and biotechnology , biology
A 19-year-old male presented with persistent macroscopic hematuria for last 3 months. On initial evaluation, he was found to have minimal proteinuria, normal renal function, and normal complement with negative lupus serology. Light microscopy, immunofluorescence and electron microscopy of renal tissue confirmed the presence of C1q nephropathy. Because of poor response to immunosuppressive agent (prednisolone and mycophenolate mofetil), passage of urinary clot once and vexing persistent macroscopic hematuria, alternative diagnosis was considered. Cystourethroscopy showed urethritis of prostatic urethra. Immunosuppressives were stopped and doxycycline started to which hematuria responded dramatically. This case report illustrates that hematuria in this patient was because of undiagnosed urethritis rather than incidental C1q nephropathy.