Open AccessRecombinant activated factor VII for diffuse alveolar hemorrhage in microscopic polyangiitis
Author(s) -
SK Mandal,
Gaurav Sagar,
Monalisa Sahoo,
Sanjiv Jasuja
Publication year - 2012
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.97134
Subject(s) - medicine , diffuse alveolar hemorrhage , microscopic polyangiitis , pulmonary hemorrhage , thrombotic microangiopathy , recombinant factor viia , granulomatosis with polyangiitis , vasculitis , complication , microangiopathy , surgery , pathology , lung , disease , diabetes mellitus , endocrinology
Diffuse alveolar hemorrhage is a serious complication of the small vessel vasculitis syndromes and carries a high mortality. Recombinant activated factor VII (rFVIIa) is a powerful hemostatic agent developed for treatment of bleeding in patients with hemophilia and antibodies to factors VIII or IX. It has been used increasingly in life-threatening hemorrhage in a variety of other settings in which conventional medical or surgical therapy is unsuccessful. We report the successful use of rFVIIa for massive pulmonary hemorrhage in a patient of microscopic polyangiitis, which was later complicated by thrombotic microangiopathy and posterior reversible encephalopathy syndrome.