Open AccessTreatment of gabapentin-induced myoclonus with continuous renal replacement therapy
Author(s) -
AK Guddati,
Zeeshan Zafar,
Cheng Jt,
Sumit Mohan
Publication year - 2012
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.83744
Subject(s) - gabapentin , medicine , renal replacement therapy , myoclonus , anesthesia , toxicity , pharmacokinetics , kidney disease , intensive care medicine , pharmacology , alternative medicine , pathology
A 56-year-old man with diabetes, hypertension, and chronic kidney disease presented to the emergency room with a complaint of pain in his right foot. He was found to have tremors. Gabapentin toxicity was suspected and the patient was found to have high gabapentin level (6.3 mcg/ml). Patient was commenced on continuous venovenous hemodiafiltration (CVVHD) and the pharmacokinetics of gabapentin was studied. The patient improved symptomatically and his tremors subsided. In this case report, we describe the successful management of gabapentin toxicity with continuous renal replacement therapy and calculate the clearance of gabapentin which will enable future treatment of gabapentin toxicity by CVVHD.