Open AccessPrerenal azotemia from excessive sweating in an adult with a cystic fibrosis gene mutation
Author(s) -
SV Tomov,
P.A. Flume,
AE Stenbit,
Ullian Me
Publication year - 2011
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.82637
Subject(s) - medicine , azotemia , cystic fibrosis , cystic fibrosis transmembrane conductance regulator , extracellular fluid , fibrosis , acute kidney injury , hyponatremia , pathology , gastroenterology , extracellular , renal function , biology , microbiology and biotechnology
We present the case of a 58-year-old male with chronic kidney disease who was admitted to the hospital multiple times with extracellular fluid volume depletion and prerenal azotemia. Some episodes were associated with gastrointestinal fluid losses and others with profuse diaphoresis in the absence of gastrointestinal fluid losses. At the age of 57 years, a common cystic fibrosis transmembrane conductance regulator protein mutation and a family history of cystic fibrosis were documented. We hypothesize that the abnormal cystic fibrosis transmembrane conductance regulator resulted in repeated bouts of excessive sweating, extracellular fluid volume depletion, and acute renal failure. This case is unique because of the prolonged period of time over which multiple documented episodes of prerenal acute renal failure occurred and because of the onset of the episodes in adulthood.