Open AccessProton pump inhibitors: More indigestion than relief?
Author(s) -
Praveen Malavade,
Swapnil Hiremath
Publication year - 2017
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.202824
Subject(s) - medicine , indigestion , hypomagnesemia , proton pump inhibitor , adverse effect , intensive care medicine , observational study , acute kidney injury , kidney disease , complication , epidemiology , proton pump , disease , magnesium , biochemistry , chemistry , materials science , atpase , metallurgy , enzyme
Proton pump inhibitors (PPIs) are widely prescribed to treat a number of gastrointestinal (GI) disorders due to excessive acid production. While effective and safe, adverse renal effects have been increasingly described in epidemiological literature. The most well-documented adverse renal outcome is acute interstitial nephritis; however, association with overall acute kidney injury has also been recently reported. Recently, two observational studies have linked PPI use with chronic kidney disease. Finally, hypomagnesemia is another reported complication and is thought to be resulting from GI loss of magnesium. This study will critically review literature on the effect of PPIs on the kidney.