Open AccessAcute ciprofloxacin-induced crystal nephropathy with granulomatous interstitial nephritis
Author(s) -
Rahim Goli,
K K Mukku,
Sree Bhushan Raju,
Megha S Uppin
Publication year - 2017
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.200522
Subject(s) - crystalluria , medicine , interstitial nephritis , acute kidney injury , ciprofloxacin , nephropathy , nephritis , rhabdomyolysis , renal function , kidney , urology , gastroenterology , urinary system , antibiotics , endocrinology , microbiology and biotechnology , calcium oxalate , diabetes mellitus , biology
Crystal-induced acute kidney injury (AKI) is caused by the intratubular precipitation of crystals, which results in obstruction and kidney injury. Ciprofloxacin, a commonly used antibiotic, causes AKI secondary to immune-mediated interstitial injury. Rare mechanisms of ciprofloxacin-induced renal injury include crystalluria, rhabdomyolysis, and granulomatous interstitial nephritis. Clinical and experimental studies have suggested that crystalluria and crystal nephropathy due to ciprofloxacin occur in alkaline urine. Preexisting kidney function impairment, high dose of the medication, and advanced age predispose to this complication. We report a case of ciprofloxacin-induced crystal nephropathy and granulomatous interstitial nephritis in a young patient with no other predisposing factors. The patient responded to conservative treatment without the need for glucocorticoids.