Open AccessHemophagocytic lymphohistiocytosis secondary to hemodialysis catheter-related blood stream infection
Author(s) -
U Anandh,
S Johari,
Bharat Vaswani
Publication year - 2017
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.180604
Subject(s) - hemophagocytosis , medicine , hemophagocytic lymphohistiocytosis , sepsis , hemodialysis , bone marrow , intensive care medicine , ferritin , hypertriglyceridemia , pathology , pancytopenia , disease , triglyceride , cholesterol
A 57-year-old man on dialysis presented with fever due to Pseudomonas septicemia. Workup revealed very high triglycerides and serum ferritin levels. A bone marrow examination showed hemophagocytosis. A diagnosis of hemophagocytic lymphohistiocytosis (HLH) was made and steroids were started. He was put on automated peritoneal dialysis. Patients' condition continued to deteriorate and he succumbed to his illness. This case illustrates the development of HLH secondary to infections which are increasingly being recognized in the literature. Often this diagnosis is missed as it becomes difficult to differentiate between sepsis and HLH. The presence of high ferritin, hypertriglyceridemia, and hemophagocytosis in the bone marrow confirms the diagnosis.