Open AccessMixed acid-base disorder secondary to topiramate use in traumatic brain injury
Author(s) -
Stephanie Golla,
Urmila Anandh,
Anandh Balasubramaniam
Publication year - 2016
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.177136
Subject(s) - hyperventilation , medicine , topiramate , respiratory alkalosis , metabolic acidosis , traumatic brain injury , anesthesia , acidosis , metabolic alkalosis , respiratory acidosis , alkalosis , pediatrics , psychiatry , epilepsy
We report a case of a man with traumatic brain injury. He was started on to prophylactic topiramate which led to a mixed acid-base disorder. He had severe metabolic acidosis secondary to renal tubular acidification defect and respiratory alkalosis secondary to hyperventilation. Withdrawal of the offending drug led to the prompt resolution of the acid-base disturbance.