Open AccessPlasma exchange in Immunoglobulin A nephropathy with thrombotic microangiopathy and acute cortical necrosis
Author(s) -
Prabhakar Doddi,
K K Gowda,
Raja Ramachandran,
Ritambhra Nada,
Vivek Kumar,
Manish Rathi,
Harbir Singh Kohli,
KL Gupta
Publication year - 2016
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.163423
Subject(s) - thrombotic microangiopathy , medicine , acute tubular necrosis , renal function , nephropathy , renal biopsy , acute kidney injury , microangiopathy , creatinine , antibody , hemolytic anemia , gastroenterology , pathology , immunology , endocrinology , diabetes mellitus , disease
A 25-year-old female presented with decreased urine output, deranged renal function, thrombocytopenia, and hemolytic anemia. Kidney biopsy was consistent with thrombotic microangiopathy with acute cortical necrosis and Immunoglobulin A nephropathy (IgAN). Hemolytic anemia, thrombocytopenia and urine output improved after five sessions of plasma exchange. Renal function showed a delayed recovery and serum creatinine normalized by 3 months. This is first case of successful use of plasma exchange in hemolytic uremic syndrome with cortical necrosis associated with IgAN.