Open AccessImmunoglobulin A dominant membranoproliferative glomerulonephritis in an elderly man: A case report and review of the literature
Author(s) -
Vinita Agrawal,
Anupma Kaul,
Ranjana Shashidhar Ranade,
RK Sharma
Publication year - 2015
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.145425
Subject(s) - membranoproliferative glomerulonephritis , medicine , cryoglobulinemia , glomerulonephritis , differential diagnosis , immunology , nephropathy , proteinuria , nephrotic syndrome , rare disease , pathology , disease , dermatology , gastroenterology , diabetes mellitus , hepatitis c virus , virus , kidney , endocrinology
Immunoglobulin A (IgA) dominant membranoproliferative glomerulonephritis (MPGN) is rare, described only as case reports. We report a rare case of an elderly man presenting with rapidly progressive renal failure and nephrotic range proteinuria with histological, immunofluorescence, and ultrastructural findings supporting a diagnosis of IgA dominant MPGN. Autoimmune disease, cryoglobulinemia and infection-associated glomerulonephritis were excluded. Remission was achieved within 3 months of treatment. This case highlights an uncommon diagnosis with a good response to therapy. The differential diagnosis of IgA nephropathy with MPGN-like pattern is discussed.