Open AccessEncephalopathy secondary to isoniazid in patients on hemodialysis
Author(s) -
Mohamed S. Abbas,
Fahmi Yousef Khan,
S Sulimon,
A Baidaa
Publication year - 2013
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.107206
Subject(s) - medicine , pyrazinamide , isoniazid , ethambutol , rifampicin , pyridoxine , encephalopathy , hemodialysis , tuberculosis , gastroenterology , pharmacology , pathology
We report isoniazid (INH)-induced encephalopathy in two male patients on hemodialysis. One of them had tuberculous adenitis, and the other had pulmonary tuberculosis. Both were given rifampicin, INH, pyrazinamide, and ethambutol with pyridoxine 40 mg/day. Two patients developed disturbances in consciousness. After excluding other causes, INH-induced encephalopathy was suspected so the drug was stopped and dose of pyridoxine increased. Both patients retained their consciousness within 1 week and were discharged.