Open AccessTransformation of membranous into anti-GBM nephritis
Author(s) -
Salman Imtiaz,
A Alswaida,
Habib ur Rehman,
N Faraz,
T Afshan,
H Alkafoury,
Shahid Qayyum,
Mohammad Al Khoiter
Publication year - 2012
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.103924
Subject(s) - membranous nephropathy , medicine , plasmapheresis , cyclophosphamide , proteinuria , glomerular basement membrane , nephritis , pathology , methylprednisolone , lupus nephritis , kidney , antibody , disease , immunology , chemotherapy
Membranous nephropathy is a common glomerular disease. We report a 50-year-old man with a history of membranous nephropathy in remission, who presented with acute kidney injury, proteinuria, hematuria, and hypertension. He also had a high anti-glomerular basement membrane (anti-GBM) antibody titer and crescent transformation of primary pathology. The kidney functions deteriorated rapidly despite aggressive therapy with cyclophosphamide, methylprednisolone, and plasmapheresis.