Open AccessCatastrophic antiphospholipid antibody syndrome in a child with thrombotic microangiopathy
Author(s) -
Narayan Prasad,
D Bhadauria,
Nitin Agarwal,
Amit Gupta,
Piyush Gupta,
Manoj Jain,
Hira Lal
Publication year - 2012
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.101266
Subject(s) - thrombotic microangiopathy , medicine , catastrophic antiphospholipid syndrome , antiphospholipid syndrome , microangiopathic hemolytic anemia , thrombosis , eculizumab , nephrology , antibody , pediatrics , immunology , gastroenterology , thrombotic thrombocytopenic purpura , disease , platelet , complement system
Thrombotic microangiopathic hemolytic anemia (TMHA) is not uncommon in clinical nephrology practice while antiphospholipid syndrome (APS) is uncommon. Although less than 1% of patients with APS develop catastrophic APS (CAPS), its potential lethal outcome because of thrombosis in multiple organs and subsequent multiorgan failure emphasizes its importance in nephrology practice. Here is a case of catastrophic APS in a 7-year-old girl, who presented to us with TMHA associated with antiphospholipid antibodies and subsequently died because of CAPS.