Open AccessA prospective, randomized, double blind and placebo-control study comparing the additive effect of oral midazolam and clonidine for postoperative nausea and vomiting prophylaxis in granisetron premedicated patients undergoing laparoscopic cholecystecomy
Author(s) -
Ghanshyam Yadav,
Biranchi Narayan Pratihary,
Gaurav Jain,
Anil Kumar Paswan,
LD Mishra
Publication year - 2013
Publication title -
journal of anaesthesiology-clinical pharmacology/journal of anaesthesiology clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.466
H-Index - 32
eISSN - 2231-2730
pISSN - 0970-9185
DOI - 10.4103/0970-9185.105800
Subject(s) - medicine , anesthesia , postoperative nausea and vomiting , antiemetic , midazolam , vomiting , clonidine , granisetron , nausea , placebo , randomized controlled trial , perioperative , premedication , ondansetron , surgery , sedation , alternative medicine , pathology
Reduction of postoperative nausea and vomiting (PONV) continues to be a major challenge in perioperative care in spite of introduction of newer antiemetics with better efficacy and safety profiles. Therefore, we evaluated the additive effect of oral midazolam and clonidine for PONV prophylaxis in granisetron premedicated patients undergoing laparoscopic cholecystectomy.