Open AccessEffect of efflux pump inhibitors on the susceptibility of Mycobacterium tuberculosis to isoniazid
Author(s) -
Indu Jaiswal,
Amita Jain,
Sanjeev Verma,
Pooja Singh,
Surya Kant,
Mastan Singh
Publication year - 2017
Publication title -
lung india
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 25
eISSN - 0974-598X
pISSN - 0970-2113
DOI - 10.4103/0970-2113.217567
Subject(s) - medicine , isoniazid , mycobacterium tuberculosis , efflux , tuberculosis , microbiology and biotechnology , pharmacology , genetics , pathology , biology
Mycobacterium can develop drug resistance (DR) by mutation of its existing gene. However, the existence of DR without mutation shows the need to look for an alternative mechanism such as the role of efflux pumps. In this study, we examined the effect of efflux pump inhibitors on isoniazid (INH) susceptibility in clinical isolates of Mycobacterium tuberculosis (Mtb).