Open AccessDiffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature
Author(s) -
Francesco Inzirillo,
Casimiro Giorgetta,
Eugenio Ravalli,
Claudio Della Pona
Publication year - 2015
Publication title -
lung india
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 25
eISSN - 0974-598X
pISSN - 0970-2113
DOI - 10.4103/0970-2113.152646
Subject(s) - valproic acid , medicine , diffuse alveolar hemorrhage , epilepsy , coagulation , clinical significance , pediatrics , psychiatry
Valproic acid (VPA) is one of the most frequently used antiepileptic drugs for the treatment of focal and generalized epilepsies, absence seizures, and Lennox-Gastaut syndrome (LGS). VPA has been demonstrated to have a negative effect on both the intrinsic and extrinsic coagulation systems and controversy exists about the clinical relevance of such hematological abnormalities. We describe a case of reversible lung hemorrage due to VPA. In English-language literature only two other similar cases (one of which fatal) have been described so far.