Open AccessUse of pleural fluid ceruloplasmin in the differentiation of exudative and transudative pleural effusion
Author(s) -
Girish Konasagara Shanthaveeranna,
Vinod G Thykadavil,
George D’Souza
Publication year - 2015
Publication title -
lung india
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 25
eISSN - 0974-598X
pISSN - 0970-2113
DOI - 10.4103/0970-2113.148419
Subject(s) - transudate , medicine , exudate , pleural effusion , ceruloplasmin , effusion , gastroenterology , pathology , pleural fluid , surgery
Differentiating into transudate or exudate is the first step in the evaluation of effusions. Light's criteria is the standard but a significant number of transudates may not be differentiated based on these criteria. Acute phase proteins (APP) are present in plasma, which increase or decrease by about 25% during an acute inflammatory response. Ceruloplasmin (CP) is a positive APP. Hence, this study was done to know the diagnostic value of pleural fluid (pf) CP and pf to serum ceruloplasmin ratio (CPr) to differentiate the pleural effusion (PE) into exudate and transudate as compared to Light's criteria.